Q: What is half life of Xigris - Recombinant Protein C (Activated) ?
A; Xigris has a short half-life, indicating rapid inactivation of Xigris after stopping infusion and more than 70% get eliminate within 30 minutes.
General recommendations are
- Discontinue Xigris 2 hours prior to performing an invasive procedure and may restart immediately after uncomplicated, less invasive procedures
- Initiation of Xigris can be considered 12 hours after major invasive procedures or surgery
- Prophylactic heparin/LMWH may be continued while patient is on xigris
Note:
- Xigris may variably prolong the APTT. Therefore, the APTT cannot be reliably used to assess the status of the coagulopathy during Xigris infusion.
- Xigris has minimal effect on the PT
