Wednesday, October 22, 2008

Wednesday October 22, 2008


Q: What is half life of Xigris - Recombinant Protein C (Activated) ?


A; Xigris has a short half-life, indicating rapid inactivation of Xigris after stopping infusion and more than 70% get eliminate within 30 minutes.

General recommendations are


  • Discontinue Xigris 2 hours prior to performing an invasive procedure and may restart immediately after uncomplicated, less invasive procedures
  • Initiation of Xigris can be considered 12 hours after major invasive procedures or surgery
  • Prophylactic heparin/LMWH may be continued while patient is on xigris

Note:

  • Xigris may variably prolong the APTT. Therefore, the APTT cannot be reliably used to assess the status of the coagulopathy during Xigris infusion.
  • Xigris has minimal effect on the PT

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